Role of Poly [ADP-ribose] Polymerase 1 in Activating the Kirsten ras (KRAS) Gene in Response to Oxidative Stress

In pancreatic Panc-1 cancer cells, an increase of oxidative stress enhances the level of 7,8-dihydro-8-oxoguanine (8OG) more in the KRAS promoter region containing G4 motifs than in non-G4 motif G-rich genomic regions. We found that H(2)O(2) stimulates the recruitment to the KRAS promoter of poly [A...

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Detalles Bibliográficos
Autores principales: Cinque, Giorgio, Ferino, Annalisa, Pedersen, Erik B., Xodo, Luigi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504130/
https://www.ncbi.nlm.nih.gov/pubmed/32872305
http://dx.doi.org/10.3390/ijms21176237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504130/
https://www.ncbi.nlm.nih.gov/pubmed/32872305
http://dx.doi.org/10.3390/ijms21176237

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