Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains

As fragment-based drug discovery has become mainstream, there has been an increase in various screening methodologies. Protein-observed (19)F (PrOF) NMR and (1)H CPMG NMR are two fragment screening assays that have complementary advantages. Here, we sought to combine these two NMR-based assays into...

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Detalles Bibliográficos
Autores principales: Johnson, Jorden A., Olson, Noelle M., Tooker, Madison J., Bur, Scott K., Pomerantz, William C.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504435/
https://www.ncbi.nlm.nih.gov/pubmed/32872491
http://dx.doi.org/10.3390/molecules25173949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504435/
https://www.ncbi.nlm.nih.gov/pubmed/32872491
http://dx.doi.org/10.3390/molecules25173949

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