Cargando…

Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity

Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. NTPDase2 has protective properties in liver fibrosis and may imp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feldbrügge, Linda, Splith, Katrin, Kämmerer, Ines, Richter, Sandra, Riddermann, Anna, Ortiz Galindo, Santiago Andres, Krenzien, Felix, Müller, Tobias, Csizmadia, Eva, Pratschke, Johann, Robson, Simon C., Schmelzle, Moritz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504458/ https://www.ncbi.nlm.nih.gov/pubmed/32825435 http://dx.doi.org/10.3390/ijms21175998

Ejemplares similares

Conserved lysine 79 is important for activity of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3)
por: Basu, Saswata, et al.
Publicado: (2004)

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3
por: Baqi, Younis, et al.
Publicado: (2020)

A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction
por: Iqbal, Jamshed, et al.
Publicado: (2005)

The structure of the nucleoside triphosphate diphosphohydrolases (NTPDases) as revealed by mutagenic and computational modeling analyses
por: Kirley, Terence L., et al.
Publicado: (2006)

Influence of Ecto-Nucleoside Triphosphate Diphosphohydrolase Activity on Trypanosoma cruzi Infectivity and Virulence
por: Santos, Ramon F., et al.
Publicado: (2009)

Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro
por: Dragic, Milorad, et al.
Publicado: (2022)

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)
por: Baqi, Younis, et al.
Publicado: (2008)

Leishmania infantum Ecto-Nucleoside Triphosphate Diphosphohydrolase-2 is an Apyrase Involved in Macrophage Infection and Expressed in Infected Dogs
por: Vasconcellos, Raphael De Souza, et al.
Publicado: (2014)

Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now
por: Zimmermann, Herbert
Publicado: (2020)

Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi
por: Silva-Gomes, Natália Lins, et al.
Publicado: (2014)

Identification of a tyrosine residue responsible for N-acetylimidazole-induced increase of activity of ecto-nucleoside triphosphate diphosphohydrolase 3
por: Basu, Saswata, et al.
Publicado: (2005)

Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications
por: Kiss, David S, et al.
Publicado: (2009)

Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 Modulates Local ATP-Induced Calcium Signaling in Human HaCaT Keratinocytes
por: Ho, Chia-Lin, et al.
Publicado: (2013)

Molecular dynamic simulations reveal structural insights into substrate and inhibitor binding modes and functionality of Ecto-Nucleoside Triphosphate Diphosphohydrolases
por: Iqbal, Jamshed, et al.
Publicado: (2018)

The Biochemical Properties of the Arabidopsis Ecto-Nucleoside Triphosphate Diphosphohydrolase AtAPY1 Contradict a Direct Role in Purinergic Signaling
por: Massalski, Carolin, et al.
Publicado: (2015)

Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis
por: Ortiz Galindo, Santiago A., et al.
Publicado: (2021)

Diagnostic Biomarkers to Diagnose Acute Allograft Rejection After Liver Transplantation: Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies
por: Krenzien, Felix, et al.
Publicado: (2019)

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase
por: Zanin, Rafael Fernandes, et al.
Publicado: (2012)

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes
por: Rodríguez-Martínez, Aitor, et al.
Publicado: (2021)

Extended liver resection in mice: state of the art and pitfalls—a systematic review
por: Kamali, Can, et al.
Publicado: (2021)

Recent Advances Clarifying the Structure and Function of Plant Apyrases (Nucleoside Triphosphate Diphosphohydrolases)
por: Clark, Greg, et al.
Publicado: (2021)

Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma
por: Luo, Jun-hua, et al.
Publicado: (2021)

Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin
por: Vorhoff, Thomas, et al.
Publicado: (2005)

Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases
por: Afzal, Saira, et al.
Publicado: (2020)

Release and extracellular metabolism of ATP by ecto-nucleotidase eNTPDase 1–2 in hypothalamic and pituitary cells
por: He, Mu-Lan, et al.
Publicado: (2005)

Ectonucleoside Triphosphate Diphosphohydrolase-1/CD39 Affects the Response to ADP of Female Rat Platelets
por: Caiazzo, Elisabetta, et al.
Publicado: (2020)

The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids
por: Brunnbauer, Philipp, et al.
Publicado: (2018)

The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family
por: MacCARTHY, CAITLIN M., et al.
Publicado: ( 201)

Simplifying minimally invasive right hepatectomy
por: Nevermann, Nora, et al.
Publicado: (2023)

Angiogenic miRNAs, the angiopoietin axis and related TIE2-expressing monocytes affect outcomes in cholangiocarcinoma
por: Atanasov, Georgi, et al.
Publicado: (2018)

Laparoscopic liver resection: indications, limitations, and economic aspects
por: Schmelzle, Moritz, et al.
Publicado: (2020)

Increased Cell-Free DNA Plasma Concentration Following Liver Transplantation Is Linked to Portal Hepatitis and Inferior Survival
por: Krenzien, Felix, et al.
Publicado: (2020)

Robotic vs. laparoscopic liver surgery: a single-center analysis of 600 consecutive patients in 6 years
por: Schmelzle, Moritz, et al.
Publicado: (2022)

Complexity-Adjusted Learning Curves for Robotic and Laparoscopic Liver Resection: A Word of Caution
por: Krenzien, Felix, et al.
Publicado: (2022)

Risk factors for malignant transformation of hepatocellular adenoma to hepatocellular carcinoma: protocol for systematic review and meta-analysis
por: Thevathasan, Tharusan, et al.
Publicado: (2021)

Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study
por: Schmelzle, Moritz, et al.
Publicado: (2022)

Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation
por: Robson, Simon C., et al.
Publicado: (1997)

Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study
por: Kamali, Kaan, et al.
Publicado: (2021)

Predicting the Risk of Postoperative Complications in Patients Undergoing Minimally Invasive Resection of Primary Liver Tumors
por: Haber, Philipp K., et al.
Publicado: (2021)

Robotic versus laparoscopic versus open major hepatectomy – an analysis of costs and postoperative outcomes in a single-center setting
por: Knitter, Sebastian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tjjprv2pib6ooi2jgjb0b4m8g5