In-Vitro and In-Silico Evaluations of Heterocyclic-Containing Diarylpentanoids as Bcl-2 Inhibitors Against LoVo Colorectal Cancer Cells

In the present study, we investigated the in-vitro anti-cancer potential of six diarylpentanoids against a panel of BRAF- and KRAS-mutated colorectal cancer cell lines including T84, SW620, LoVo, HT29, NCI-H508, RKO, and LS411N cells. Structure–activity relationship study suggested that the insertio...

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Detalles Bibliográficos
Autores principales: Leong, Sze Wei, Chia, Suet Lin, Abas, Faridah, Yusoff, Khatijah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504466/
https://www.ncbi.nlm.nih.gov/pubmed/32858795
http://dx.doi.org/10.3390/molecules25173877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504466/
https://www.ncbi.nlm.nih.gov/pubmed/32858795
http://dx.doi.org/10.3390/molecules25173877

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