Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response

Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against different cellular stresses, such as accumulation of misfolded proteins. Unlike g...

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Detalles Bibliográficos
Autores principales: Ruiz, Asier, Zuazo, Jone, Ortiz-Sanz, Carolina, Luchena, Celia, Matute, Carlos, Alberdi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504470/
https://www.ncbi.nlm.nih.gov/pubmed/32846985
http://dx.doi.org/10.3390/ijms21176088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504470/
https://www.ncbi.nlm.nih.gov/pubmed/32846985
http://dx.doi.org/10.3390/ijms21176088

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