Cargando…

Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium

Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1. The presence of HS is a prerequisite for the syndecan-1 c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Changrim, Edman, Maria C., Laurie, Gordon W., Hamm-Alvarez, Sarah F., MacKay, J. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504496/ https://www.ncbi.nlm.nih.gov/pubmed/32859014 http://dx.doi.org/10.3390/ijms21176157

Ejemplares similares

Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms
por: Justis, Brooke M., et al.
Publicado: (2020)

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death
por: Vantaku, Venkat Rao, et al.
Publicado: (2015)

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome
por: McNamara, Nancy A., et al.
Publicado: (2016)

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis
por: Georgiev, Georgi A., et al.
Publicado: (2020)

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye
por: Hsueh, Pang-Yu, et al.
Publicado: (2020)

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin
por: Ma, Peisong, et al.
Publicado: (2006)

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin
por: Ma, Peisong, et al.
Publicado: (2011)

Restricted epithelial proliferation by lacritin via PKCα-dependent NFAT and mTOR pathways
por: Wang, Jiahu, et al.
Publicado: (2006)

Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses
por: Wang, Wan, et al.
Publicado: (2019)

Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome
por: Klinngam, Wannita, et al.
Publicado: (2019)

Resolution of Eczema with Multivalent Peptides
por: Eggink, Laura L., et al.
Publicado: (2022)

Exosomes combined with biosynthesized cellulose conduits improve peripheral nerve regeneration
por: Cui, Tian-Wei, et al.
Publicado: (2023)

Mechanobiology of the corneal epithelium
por: Masterton, Sophia, et al.
Publicado: (2018)

Biosynthesized nanomaterials /
Publicado: (2021)

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease—Activated Receptor-2, in Human Corneal Epithelial Cells
por: Klinngam, Wannita, et al.
Publicado: (2018)

An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols
por: Aldahlawi, Nada H., et al.
Publicado: (2016)

Synthetic Multivalent Antifungal Peptides Effective against Fungi
por: Lakshminarayanan, Rajamani, et al.
Publicado: (2014)

Impact of multivalent charge presentation on peptide–nanoparticle aggregation
por: Schöne, Daniel, et al.
Publicado: (2015)

Multivalent Peptide–Nanoparticle Conjugates for Influenza‐Virus Inhibition
por: Lauster, Daniel, et al.
Publicado: (2017)

Anti-Fungal Hevein-like Peptides Biosynthesized from Quinoa Cleavable Hololectins
por: Loo, Shining, et al.
Publicado: (2021)

Inflammatory profile of keratoconic corneal epithelium
por: Marques, Junia Cabral, et al.
Publicado: (2023)

VACUOLES IN THE EMBRYONIC CHICK CORNEAL EPITHELIUM, AN EPITHELIUM WHICH PRODUCES COLLAGEN
por: Trelstad, Robert L.
Publicado: (1971)

Pigment Epithelium-Derived Factor Peptide Promotes Corneal Nerve Regeneration: An In Vivo and In Vitro Study
por: Yeh, Shu-I, et al.
Publicado: (2021)

Abstract 8: Corneal Neurotization Rescues the Corneal Epithelium from Thinning in a Rat Model of Neurotrophic Keratopathy
por: Antonyshyn, Kira, et al.
Publicado: (2019)

Cytochromes P450 Associated with the Biosyntheses of Ribosomally Synthesized and Post-translationally Modified Peptides
por: Zhong, Guannan
Publicado: (2023)

Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities
por: Liu, S. P., et al.
Publicado: (2010)

Multivalent display of the antimicrobial peptides BP100 and BP143
por: Güell, Imma, et al.
Publicado: (2012)

Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
por: Thomas, Christoph, et al.
Publicado: (2017)

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells
por: Guidotti, Nora, et al.
Publicado: (2022)

The Oxidant Role of 4-Hydroxynonenal in Corneal Epithelium
por: Chen, Longlong, et al.
Publicado: (2015)

Morphological and immunohistochemical characteristics of the equine corneal epithelium
por: Kammergruber, Eva, et al.
Publicado: (2019)

Wound healing of the corneal epithelium: a review
por: Ghafar, Norzana Abd, et al.
Publicado: (2021)

Features of p53 protein distribution in the corneal epithelium and corneal tear film
por: Tendler, Yevgeny, et al.
Publicado: (2020)

Carotenoids in Algae: Distributions, Biosyntheses and Functions
por: Takaichi, Shinichi
Publicado: (2011)

The invertebrate Caenorhabditis elegans biosynthesizes ascorbate
por: Patananan, Alexander N., et al.
Publicado: (2015)

Biosynthesized silver nanoparticles: are they effective antimicrobials?
por: Peiris, Mudara K, et al.
Publicado: (2017)

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW
por: Henning, Lisa Maria, et al.
Publicado: (2015)

Solid-Phase Synthesis of Self-Assembling Multivalent π-Conjugated Peptides
por: Sanders, Allix M., et al.
Publicado: (2017)

Molecular Dynamics Simulations of a Catalytic Multivalent Peptide–Nanoparticle Complex
por: Dutta, Sutapa, et al.
Publicado: (2021)

A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
por: Gallego, Iván, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_73kf022r0hlt0tdh8f3or038ti