Cargando…

ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation

ADAR (adenosine deaminase acting on RNA) catalyzes the deamination of adenosine to generate inosine, through its binding to double-stranded RNA (dsRNA), a phenomenon known as RNA editing. One of the functions of ADAR1 is suppressing the type I interferon (IFN) response, but its mechanism in gastric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Lushang, Park, Min Ji, Cho, Charles J., Lee, Kihak, Jung, Min Kyo, Pack, Chan Gi, Myung, Seung-Jae, Chang, Suhwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504523/ https://www.ncbi.nlm.nih.gov/pubmed/32867271 http://dx.doi.org/10.3390/ijms21176195

Ejemplares similares

ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer
por: Cho, Charles J., et al.
Publicado: (2017)

RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN
por: Park, Min Ji, et al.
Publicado: (2023)

ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling
por: Hartner, Jochen C., et al.
Publicado: (2008)

Corrigendum to: RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN
por: Park, Min Ji, et al.
Publicado: (2023)

ADAR1 averts fatal type I interferon induction by ZBP1
por: Jiao, Huipeng, et al.
Publicado: (2022)

Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
por: Sobhkhez, Mehrdad, et al.
Publicado: (2014)

Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
por: Blanco, Jorge C. G., et al.
Publicado: (2000)

Interferons and IRF/Stat transcription factors in the regulation of immunity, oncogenesis and bone remodeling
por: Taniguchi, T, et al.
Publicado: (2003)

Properties of STAT1 and IRF1 enhancers and the influence of SNPs
por: Abou El Hassan, Mohamed, et al.
Publicado: (2017)

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells
por: Horiuchi, Makoto, et al.
Publicado: (2011)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Hyper-activated IRF-1 and STAT1 contribute to enhanced Interferon stimulated gene (ISG) expression by Interferon α and γ co-treatment in human hepatoma cells
por: Zhang, Xiao-Nan, et al.
Publicado: (2006)

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes
por: McEntee, Cali M., et al.
Publicado: (2023)

The microRNA and the perspectives of miR-302
por: Chen, Emily Yen Yu, et al.
Publicado: (2019)

PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
por: Zhao, Xin, et al.
Publicado: (2022)

Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
por: Liang, Ji, et al.
Publicado: (2015)

Activation of IFN-γ/STAT/IRF-1 in Hepatic Responses to Klebsiella pneumoniae Infection
por: Lin, Yi-Chun, et al.
Publicado: (2013)

HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction
por: Lin, Lan, et al.
Publicado: (2014)

Down-regulation of miR-302b, an ESC-specific microRNA, in Gastric Adenocarcinoma
por: Khalili, Mitra, et al.
Publicado: (2012)

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection
por: Irving, Aaron T., et al.
Publicado: (2020)

Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment
por: Lin, Weiwei, et al.
Publicado: (2023)

ADAR mediates differential expression of polycistronic microRNAs
por: Chawla, Geetanjali, et al.
Publicado: (2014)

ADAR1 restricts LINE-1 retrotransposition
por: Orecchini, Elisa, et al.
Publicado: (2017)

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
por: Feng, Hui, et al.
Publicado: (2021)

IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1 signaling in EBV-positive gastric carcinoma
por: Moon, Ji Wook, et al.
Publicado: (2017)

Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
por: Fanzo, Jessica C., et al.
Publicado: (2003)

IRF1 regulates the progression of colorectal cancer via interferon-induced proteins
por: Xu, Xiaohui, et al.
Publicado: (2021)

ADAR1 affects gastric cancer cell metastasis and reverses cisplatin resistance through AZIN1
por: Wang, Honghong, et al.
Publicado: (2023)

STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes
por: Edsbäcker, Elin, et al.
Publicado: (2019)

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
por: Platanitis, Ekaterini, et al.
Publicado: (2019)

A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism
por: Salem, Sandra, et al.
Publicado: (2014)

Molecular characterization and antiviral effects of canine interferon regulatory factor 1 (CaIRF1)
por: Hao, Xiangqi, et al.
Publicado: (2022)

ADAR1-mediated regulation of melanoma invasion
por: Nemlich, Yael, et al.
Publicado: (2018)

ADAR1 Editing and its Role in Cancer
por: Xu, Li-Di, et al.
Publicado: (2018)

Application of the microRNA‐302/367 cluster in cancer therapy
por: Liu, Jiajia, et al.
Publicado: (2020)

Up-Regulation of Intestinal Epithelial Cell Derived IL-7 Expression by Keratinocyte Growth Factor through STAT1/IRF-1, IRF-2 Pathway
por: Cai, Yu-Jiao, et al.
Publicado: (2013)

MicroRNA-302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1
por: Jiang, Yongjie, et al.
Publicado: (2022)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β
por: Bakshi, Siddharth, et al.
Publicado: (2017)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j6indp863l1hnqnts9q73a3pam