Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib

BACKGROUND: Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, including ovarian cancer. The purpose of this study was to investigate the biologic...

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Detalles Bibliográficos
Autores principales: Liu, Lidong, Zhang, Zhiwei, Zhang, Guoxiang, Wang, Ting, Ma, Yingchun, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504643/
https://www.ncbi.nlm.nih.gov/pubmed/32951601
http://dx.doi.org/10.1186/s12967-020-02528-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504643/
https://www.ncbi.nlm.nih.gov/pubmed/32951601
http://dx.doi.org/10.1186/s12967-020-02528-0

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