Cargando…

Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib

BACKGROUND: Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, including ovarian cancer. The purpose of this study was to investigate the biologic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Lidong, Zhang, Zhiwei, Zhang, Guoxiang, Wang, Ting, Ma, Yingchun, Guo, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504643/ https://www.ncbi.nlm.nih.gov/pubmed/32951601 http://dx.doi.org/10.1186/s12967-020-02528-0

Ejemplares similares

Olaparib in Epithelial Ovarian Cancer
por: Anastasia, Paula J.
Publicado: (2016)

PADI4-mediated epithelial-mesenchymal transition in lung cancer cells
por: Liu, Meiyan, et al.
Publicado: (2019)

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
por: Colomiere, M, et al.
Publicado: (2009)

Ribonucleotide reductase subunit M2 promotes proliferation and epithelial–mesenchymal transition via the JAK2/STAT3 signaling pathway in retinoblastoma
por: Yang, Min, et al.
Publicado: (2021)

Olaparib in the management of ovarian cancer
por: Bixel, Kristin, et al.
Publicado: (2015)

Oridonin represses epithelial-mesenchymal transition and angiogenesis of thyroid cancer via downregulating JAK2/STAT3 signaling
por: Liu, Wei, et al.
Publicado: (2022)

PADI4 promotes epithelial-mesenchymal transition(EMT) in gastric cancer via the upregulation of interleukin 8
por: Chang, Xiao-tian, et al.
Publicado: (2022)

Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice
por: Sams, Kelly L., et al.
Publicado: (2022)

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib
por: Whicker, Margaret E., et al.
Publicado: (2016)

RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis
por: Huang, Yuting, et al.
Publicado: (2014)

PADI2 Is Significantly Associated with Rheumatoid Arthritis
por: Chang, Xiaotian, et al.
Publicado: (2013)

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
por: Coassolo, Sébastien, et al.
Publicado: (2021)

STEAP1 facilitates metastasis and epithelial–mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway
por: Huo, Shu-fen, et al.
Publicado: (2020)

PADI4 and tumourigenesis
por: Chang, Xiaotian, et al.
Publicado: (2010)

ENC1 Facilitates Colorectal Carcinoma Tumorigenesis and Metastasis via JAK2/STAT5/AKT Axis-Mediated Epithelial Mesenchymal Transition and Stemness
por: Cui, Ying, et al.
Publicado: (2021)

Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors
por: Guo, Wei, et al.
Publicado: (2017)

Nitidine chloride suppresses epithelial‐mesenchymal transition and stem cell‐like properties in glioblastoma by regulating JAK2/STAT3 signaling
por: Jia, Mingbo, et al.
Publicado: (2021)

PERK-Dependent Activation of the JAK2/STAT3 Pathway Contributes to High Glucose-Induced Extracellular Matrix Deposition in Renal Tubular Epithelial Cells
por: Bao, Yan, et al.
Publicado: (2021)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients
por: Nava-Quiroz, Karol J., et al.
Publicado: (2023)

Basic Transcription Factor 3 Is Required for Proliferation and Epithelial–Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer
por: Zhang, De-Zhong, et al.
Publicado: (2017)

Corrigendum: ENC1 Facilitates Colorectal Carcinoma Tumorigenesis and Metastasis via JAK2/STAT5/AKT Axis-Mediated Epithelial Mesenchymal Transition and Stemness
por: Cui, Ying, et al.
Publicado: (2021)

Profile of olaparib in the treatment of advanced ovarian cancer
por: Chase, Dana M, et al.
Publicado: (2016)

CHAF1A promotes the proliferation and growth of epithelial ovarian cancer cells by affecting the phosphorylation of JAK2/STAT3 signaling pathway
por: Xia, Dandan, et al.
Publicado: (2023)

Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan
por: Alaaeldin, Rania, et al.
Publicado: (2022)

Expression of Concern: STEAP1 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the JAK2/STAT3 signaling pathway
Publicado: (2023)

Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines
por: Gralewska, Patrycja, et al.
Publicado: (2021)

Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia
por: Han, Xiaotian, et al.
Publicado: (2021)

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris
por: Juczynska, K., et al.
Publicado: (2020)

Acute myeloid leukemia (AML)‐derived mesenchymal stem cells induce chemoresistance and epithelial–mesenchymal transition‐like program in AML through IL‐6/JAK2/STAT3 signaling
por: Lu, Jianle, et al.
Publicado: (2023)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

JAK-STAT and feeding
por: Ladyman, Sharon R., et al.
Publicado: (2013)

Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis
por: Lin, Rui, et al.
Publicado: (2023)

MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
por: Yi, Jingyan, et al.
Publicado: (2019)

Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma
por: Dong, Yanxu, et al.
Publicado: (2023)

Scutellarin inhibits proliferation and invasion of hepatocellular carcinoma cells via down‐regulation of JAK2/STAT3 pathway
por: Liu, Kang, et al.
Publicado: (2019)

Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy
por: Koppikar, Priya, et al.
Publicado: (2012)

PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells
por: Liu, Ying, et al.
Publicado: (2022)

B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway
por: Kang, Fu-biao, et al.
Publicado: (2015)

Down-regulation of SOX18 inhibits laryngeal carcinoma cell proliferation, migration, and invasion through JAK2/STAT3 signaling
por: Xu, Yice, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s3rc1tsiikci05qo5mod5fl1p6