SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) immunotherapy with antibodies targeting amyloid-β (Aβ) has been extensively explored in clinical trials. The aim of this study was to study the long-term brain distribution of two radiolabeled monoclonal Aβ antibody variants – RmAb158, the recombinant murine vers...

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Detalles Bibliográficos
Autores principales: Gustavsson, Tobias, Syvänen, Stina, O’Callaghan, Paul, Sehlin, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504681/
https://www.ncbi.nlm.nih.gov/pubmed/32951598
http://dx.doi.org/10.1186/s40035-020-00214-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504681/
https://www.ncbi.nlm.nih.gov/pubmed/32951598
http://dx.doi.org/10.1186/s40035-020-00214-1

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