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Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases. Yet, C1r-targeted therapeutic development is currently underrepresented relative to other complement targets....

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Detalles Bibliográficos
Autores principales: Rushing, Blake R., Rohlik, Denise L., Roy, Sourav, Skaff, D. Andrew, Garcia, Brandon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504721/
https://www.ncbi.nlm.nih.gov/pubmed/32899120
http://dx.doi.org/10.3390/molecules25174016