16-Hydroxycleroda-3,13-Dien-15,16-Olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways

A clerodane diterpene compound 16-hydroxycleroda-3,13-dien-15,16-olide (CD) is considered a therapeutic agent with pharmacological activities. The present study investigated the mechanisms of CD-induced apoptosis in T24 human bladder cancer cells. CD inhibited cell proliferation in a concentration a...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Chi, Wang, Po-Yu, Huang, Bu-Miin, Chen, Yu-Jen, Lee, Wei-Chang, Chen, Yung-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504739/
https://www.ncbi.nlm.nih.gov/pubmed/32872665
http://dx.doi.org/10.3390/molecules25173958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504739/
https://www.ncbi.nlm.nih.gov/pubmed/32872665
http://dx.doi.org/10.3390/molecules25173958

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