The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1

Human apurinic/apyrimidinic (AP) endonuclease APE1 hydrolyzes phosphodiester bonds on the 5′ side of an AP-site, and some damaged nucleotides such as 1,N6-ethenoadenosine (εA), α-adenosine (αA), and 5,6-dihydrouridine (DHU). To investigate the mechanism behind the broad substrate specificity of APE1...

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Detalles Bibliográficos
Autores principales: Bulygin, Anatoly A., Kuznetsova, Alexandra A., Vorobjev, Yuri N., Fedorova, Olga S., A. Kuznetsov, Nikita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504742/
https://www.ncbi.nlm.nih.gov/pubmed/32872297
http://dx.doi.org/10.3390/molecules25173940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504742/
https://www.ncbi.nlm.nih.gov/pubmed/32872297
http://dx.doi.org/10.3390/molecules25173940

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