Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors—In Vitro, In Silico and QSAR Studies

A series of nineteen amino acid analogues of amantadine (Amt) and rimantadine (Rim) were synthesized and their antiviral activity was evaluated against influenza virus A (H3N2). Among these analogues, the conjugation of rimantadine with glycine illustrated high antiviral activity combined with low c...

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Detalles Bibliográficos
Autores principales: Chayrov, Radoslav, Parisis, Nikolaos A., Chatziathanasiadou, Maria V., Vrontaki, Eleni, Moschovou, Kalliopi, Melagraki, Georgia, Sbirkova-Dimitrova, Hristina, Shivachev, Boris, Schmidtke, Michaela, Mitrev, Yavor, Sticha, Martin, Mavromoustakos, Thomas, Tzakos, Andreas G., Stankova, Ivanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504818/
https://www.ncbi.nlm.nih.gov/pubmed/32883012
http://dx.doi.org/10.3390/molecules25173989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504818/
https://www.ncbi.nlm.nih.gov/pubmed/32883012
http://dx.doi.org/10.3390/molecules25173989

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