SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

BACKGROUND: Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyrosine phosphatase (PTPs), which play a significant role in maintaining immunolo...

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Detalles Bibliográficos
Autores principales: Jiang, Jihong, Hu, Baoji, Chung, Chun-Shiang, Chen, Yaping, Zhang, Yunhe, Tindal, Elizabeth W., Li, Jinbao, Ayala, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504828/
https://www.ncbi.nlm.nih.gov/pubmed/32957908
http://dx.doi.org/10.1186/s10020-020-00210-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504828/
https://www.ncbi.nlm.nih.gov/pubmed/32957908
http://dx.doi.org/10.1186/s10020-020-00210-1

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