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Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS

BACKGROUND: Microglia, the primary resident myeloid cells of the brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. However, microglial activation and dysfunction has been implicated in a number of central nervous system (CNS) disorder...

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Detalles Bibliográficos
Autores principales: Hohsfield, Lindsay A., Najafi, Allison R., Ghorbanian, Yasamine, Soni, Neelakshi, Hingco, Edna E., Kim, Sung Jin, Jue, Ayer Darling, Swarup, Vivek, Inlay, Mathew A., Green, Kim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504855/
https://www.ncbi.nlm.nih.gov/pubmed/32951604
http://dx.doi.org/10.1186/s12974-020-01931-0