Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

BACKGROUND: In animal models of ventilation-induced lung injury, mitophagy triggers mitochondria damage and the release of mitochondrial (mt) DNA, which activates inflammation. However, the mechanism of this process is unclear. METHODS: A model of cyclic stretching (CS)-induced lung epithelial cell...

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Detalles Bibliográficos
Autores principales: Jing, Ren, Hu, Zhao-Kun, Lin, Fei, He, Sheng, Zhang, Sui-Sui, Ge, Wan-Yun, Dai, Hui-jun, Du, Xue-Ke, Lin, Jin-Yuan, Pan, Ling-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504878/
https://www.ncbi.nlm.nih.gov/pubmed/33015037
http://dx.doi.org/10.3389/fcell.2020.00819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504878/
https://www.ncbi.nlm.nih.gov/pubmed/33015037
http://dx.doi.org/10.3389/fcell.2020.00819

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