Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid

BACKGROUND: The mechanisms of how APOE ɛ4 allele (APOE4) increases the risk of Alzheimer’s disease (AD) pathology have not been fully elucidated. In cerebrospinal fluid (CSF), apoE is heavily glycosylated. OBJECTIVE: To determine the impact of APOE genotype on the relative abundance of apoE protein...

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Detalles Bibliográficos
Autores principales: Hu, Yueming, Meuret, Cristiana, Go, Scholastica, Yassine, Hussein N., Nedelkov, Dobrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504994/
https://www.ncbi.nlm.nih.gov/pubmed/32568201
http://dx.doi.org/10.3233/JAD-200203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504994/
https://www.ncbi.nlm.nih.gov/pubmed/32568201
http://dx.doi.org/10.3233/JAD-200203

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