Cargando…

Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway

BACKGROUND: The application of apatinib is immensely limited by its acquired drug resistance. This research investigates whether cordycepin, a component from Cordyceps could synergize with apatinib to improve its anticancer effect on non-small cell lung cancer (NSCLC) cells. METHODS: The NSCLC cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Xiaozhong, Tao, Lanting, Guo, Wei, Wu, Zhuo-Xun, Du, Haiyan, Wang, Jing, Zhang, Jue, Chen, Hanrui, Chen, Zhe-Sheng, Lin, Lizhu, Sun, Lingling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505117/ https://www.ncbi.nlm.nih.gov/pubmed/33014856 http://dx.doi.org/10.3389/fonc.2020.01732

Ejemplares similares

Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer
por: Feng, Chen, et al.
Publicado: (2023)

Chinese and Western Integrative Medicine for Stage IIIb-IVb Non-Small Cell Lung Cancer: Design and Rationale of a Multi-center, Prospective Registry (NSCLC-Chinese and Western Integrative Medicine cohort)
por: Lin, Jietao, et al.
Publicado: (2023)

Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
por: Peng, Hong, et al.
Publicado: (2016)

Zhengyuan capsules for the treatment of chemotherapy-induced cancer-related fatigue in stage IIIB–IV unresectable NSCLC: study protocol for a randomized, multi-center, double-blind, placebo-controlled clinical trial
por: Lin, Jietao, et al.
Publicado: (2022)

Efficacy of Osimertinib in NSCLC Harboring Uncommon EGFR L861Q and Concurrent Mutations: Case Report and Literature Review
por: Lin, Ruiting, et al.
Publicado: (2021)

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway
por: Li, Hong-Bo, et al.
Publicado: (2021)

The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC
por: Zhou, Ling, et al.
Publicado: (2023)

Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways
por: Song, Jifu, et al.
Publicado: (2021)

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi
por: Qin, Peng, et al.
Publicado: (2019)

Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris
por: Wang, Li, et al.
Publicado: (2022)

Apatinib sensitizes chemoresistant NSCLC cells to doxetaxel via regulating autophagy and enhances the therapeutic efficacy in advanced and refractory/recurrent NSCLC
por: Hu, Rong, et al.
Publicado: (2020)

Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway
por: Liao, Xiao-Zhong, et al.
Publicado: (2017)

Significant efficacy and well safety of apatinib combined with radiotherapy in NSCLC: Case report
por: Zhao, Chunbo, et al.
Publicado: (2017)

Synergistic Lethality Effects of Apatinib and Homoharringtonine in Acute Myeloid Leukemia
por: Shi, Yuanfei, et al.
Publicado: (2022)

Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatigue
por: Guo, Wei, et al.
Publicado: (2021)

Yifei Sanjie Formula or Placebo With Anlotinib as Second-Line or Above Treatment for Metastatic Non-Small-Cell Lung Cancer: Study Protocol for a Double-Blind, Placebo-Controlled Randomized Pilot Study
por: Chen, Wenmin, et al.
Publicado: (2023)

Sunitinib-and-Chinese herbal medicine-based systematic treatment clinically cured a patient with multiple metastatic primary clear cell carcinoma of the liver: a case report
por: Sun, Lingling, et al.
Publicado: (2019)

Mechanism of Activation of AMPK by Cordycepin
por: Hawley, Simon A., et al.
Publicado: (2020)

Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi
por: Qin, Peng, et al.
Publicado: (2019)

Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway
por: Wang, Yue, et al.
Publicado: (2017)

Cordycepin inhibits colon cancer proliferation by suppressing MYC expression
por: Zhang, Zhe, et al.
Publicado: (2022)

Apatinib with EGFR-TKIs in advanced wild gene-type NSCLC: A case report
por: Wu, Yuan-Peng, et al.
Publicado: (2019)

Apatinib Plus Chemotherapy Shows Clinical Activity in Advanced NSCLC: A Retrospective Study
por: Tang, Jing, et al.
Publicado: (2019)

Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway
por: Gao, Ying, et al.
Publicado: (2020)

Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report
por: Yang, Lishu, et al.
Publicado: (2018)

Efficacy and safety of apatinib as third- or further-line therapy for patients with advanced NSCLC: a retrospective study
por: Liang, Jianmiao, et al.
Publicado: (2020)

Application of apatinib after multifaceted therapies for metastatic breast cancer
por: Wang, Jue, et al.
Publicado: (2020)

Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation
por: Alamoudi, Abdulmohsin J., et al.
Publicado: (2022)

Significant Benefits of Afatinib and Apatinib in a Refractory Advanced NSCLC Patient Resistant to Osimertinib: A Case Report
por: Zhao, Yuanyang, et al.
Publicado: (2021)

Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway
por: Liao, Xiao-Zhong, et al.
Publicado: (2021)

The Anticancer Properties of Cordycepin and Their Underlying Mechanisms
por: Yoon, So Young, et al.
Publicado: (2018)

Chidamide and apatinib are therapeutically synergistic in acute myeloid leukemia stem and progenitor cells
por: Zhao, Haijun, et al.
Publicado: (2022)

Apatinib inhibits the growth of small cell lung cancer via a mechanism mediated by VEGF, PI3K/Akt and Ki‐67/CD31
por: Zhong, Ning, et al.
Publicado: (2021)

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin
por: Chen, Yu-Ying, et al.
Publicado: (2021)

Integration of network pharmacology and molecular docking to explore the molecular mechanism of Cordycepin in the treatment of Alzheimer’s disease
por: Ma, Xiaoying, et al.
Publicado: (2022)

The suppressing effects of VEGF-mediated angiogenesis at different administration sequences of apatinib and transarterial embolization in vivo
por: Li, Nan, et al.
Publicado: (2020)

Development of an efficient method for separation and purification of cordycepin from liquid fermentation of Cordyceps militaris and analysis of cordycepin antitumor activity
por: Liu, Peng-xiao, et al.
Publicado: (2023)

Apatinib inhibits the proliferation of gastric cancer cells via the AKT/GSK signaling pathway in vivo
por: Chen, Yi, et al.
Publicado: (2021)

Apatinib as a third- or further- line treatment in patients with advanced NSCLC harboring wild-type EGFR
por: Fang, Shencun, et al.
Publicado: (2017)

In vitro and in vivo analyses on anti-NSCLC activity of apatinib: rediscovery of a new drug target V600E mutation
por: Chen, Jiani, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tnt3s66bh53tmjrir2d5ki8rk1