Firing rate homeostasis counteracts changes in stability of recurrent neural networks caused by synapse loss in Alzheimer’s disease

The impairment of cognitive function in Alzheimer’s disease is clearly correlated to synapse loss. However, the mechanisms underlying this correlation are only poorly understood. Here, we investigate how the loss of excitatory synapses in sparsely connected random networks of spiking excitatory and...

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Detalles Bibliográficos
Autores principales: Bachmann, Claudia, Tetzlaff, Tom, Duarte, Renato, Morrison, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505475/
https://www.ncbi.nlm.nih.gov/pubmed/32841234
http://dx.doi.org/10.1371/journal.pcbi.1007790

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