Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

K-RAS is known as the most frequently mutated oncogene. However, the development of conventional K-RAS inhibitors has been extremely challenging, with a mutation-specific inhibitor reaching clinical trials only recently. Targeted proteolysis has emerged as a new modality in drug discovery to tackle...

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Detalles Bibliográficos
Autores principales: Röth, Sascha, Macartney, Thomas J., Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505679/
https://www.ncbi.nlm.nih.gov/pubmed/32668202
http://dx.doi.org/10.1016/j.chembiol.2020.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505679/
https://www.ncbi.nlm.nih.gov/pubmed/32668202
http://dx.doi.org/10.1016/j.chembiol.2020.06.012

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