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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
K-RAS is known as the most frequently mutated oncogene. However, the development of conventional K-RAS inhibitors has been extremely challenging, with a mutation-specific inhibitor reaching clinical trials only recently. Targeted proteolysis has emerged as a new modality in drug discovery to tackle...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505679/ https://www.ncbi.nlm.nih.gov/pubmed/32668202 http://dx.doi.org/10.1016/j.chembiol.2020.06.012 |