Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chemically tuneable AdPROM system is more desirable. Here, we use...

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Detalles Bibliográficos
Autores principales: Simpson, Luke M., Macartney, Thomas J., Nardin, Alice, Fulcher, Luke J., Röth, Sascha, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Ganley, Ian G., Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505680/
https://www.ncbi.nlm.nih.gov/pubmed/32668203
http://dx.doi.org/10.1016/j.chembiol.2020.06.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505680/
https://www.ncbi.nlm.nih.gov/pubmed/32668203
http://dx.doi.org/10.1016/j.chembiol.2020.06.013

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