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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chemically tuneable AdPROM system is more desirable. Here, we use...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505680/ https://www.ncbi.nlm.nih.gov/pubmed/32668203 http://dx.doi.org/10.1016/j.chembiol.2020.06.013 |