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Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its substrates, both after pulmonary and systemic administration. To better understand the molecular mechanisms involved...
Autores principales: | Selo, Mohammed Ali, Delmas, Anne-Sophie, Springer, Lisa, Zoufal, Viktoria, Sake, Johannes A., Clerkin, Caoimhe G., Huwer, Hanno, Schneider-Daum, Nicole, Lehr, Claus-Michael, Nickel, Sabrina, Langer, Oliver, Ehrhardt, Carsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505930/ https://www.ncbi.nlm.nih.gov/pubmed/33015009 http://dx.doi.org/10.3389/fbioe.2020.01030 |
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