Connexin26 mediates CO(2)-dependent regulation of breathing via glial cells of the medulla oblongata

Breathing is highly sensitive to the PCO(2) of arterial blood. Although CO(2) is detected via the proxy of pH, CO(2) acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural motif of CO(2)-binding to Cx26 to devise a dominant negati...

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Detalles Bibliográficos
Autores principales: van de Wiel, Joseph, Meigh, Louise, Bhandare, Amol, Cook, Jonathan, Nijjar, Sarbjit, Huckstepp, Robert, Dale, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505967/
https://www.ncbi.nlm.nih.gov/pubmed/32958814
http://dx.doi.org/10.1038/s42003-020-01248-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505967/
https://www.ncbi.nlm.nih.gov/pubmed/32958814
http://dx.doi.org/10.1038/s42003-020-01248-x

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