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Connexin26 mediates CO(2)-dependent regulation of breathing via glial cells of the medulla oblongata
Breathing is highly sensitive to the PCO(2) of arterial blood. Although CO(2) is detected via the proxy of pH, CO(2) acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural motif of CO(2)-binding to Cx26 to devise a dominant negati...
Autores principales: | van de Wiel, Joseph, Meigh, Louise, Bhandare, Amol, Cook, Jonathan, Nijjar, Sarbjit, Huckstepp, Robert, Dale, Nicholas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505967/ https://www.ncbi.nlm.nih.gov/pubmed/32958814 http://dx.doi.org/10.1038/s42003-020-01248-x |
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