Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1

The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation of U2AF1 can cause serious disease such as certain cancers or myelodysplasti...

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Detalles Bibliográficos
Autores principales: Yoshida, Hisashi, Park, Sam-Yong, Sakashita, Gyosuke, Nariai, Yuko, Kuwasako, Kanako, Muto, Yutaka, Urano, Takeshi, Obayashi, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505975/
https://www.ncbi.nlm.nih.gov/pubmed/32958768
http://dx.doi.org/10.1038/s41467-020-18559-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505975/
https://www.ncbi.nlm.nih.gov/pubmed/32958768
http://dx.doi.org/10.1038/s41467-020-18559-6

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