Identification of pathogenic missense mutations using protein stability predictors

Attempts at using protein structures to identify disease-causing mutations have been dominated by the idea that most pathogenic mutations are disruptive at a structural level. Therefore, computational stability predictors, which assess whether a mutation is likely to be stabilising or destabilising...

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Detalles Bibliográficos
Autores principales: Gerasimavicius, Lukas, Liu, Xin, Marsh, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506547/
https://www.ncbi.nlm.nih.gov/pubmed/32958805
http://dx.doi.org/10.1038/s41598-020-72404-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506547/
https://www.ncbi.nlm.nih.gov/pubmed/32958805
http://dx.doi.org/10.1038/s41598-020-72404-w

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