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DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity
Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue have not been undertaken. Using 850K DNA methylation arrays we compared the...
Autores principales: | Turner, D. C., Gorski, P. P., Maasar, M. F., Seaborne, R. A., Baumert, P., Brown, A. D., Kitchen, M. O., Erskine, R. M., Dos-Remedios, I., Voisin, S., Eynon, N., Sultanov, R. I., Borisov, O. V., Larin, A. K., Semenova, E. A., Popov, D. V., Generozov, E. V., Stewart, C. E., Drust, B., Owens, D. J., Ahmetov, I. I., Sharples, A. P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506549/ https://www.ncbi.nlm.nih.gov/pubmed/32958812 http://dx.doi.org/10.1038/s41598-020-72730-z |
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