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Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction
Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia. Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these changes are adaptive or maladaptive. To directly evaluate the relationship between glucose delivery and mitochondrial dy...
Autores principales: | Wende, Adam R., Schell, John C., Ha, Chae-Myeong, Pepin, Mark E., Khalimonchuk, Oleh, Schwertz, Hansjörg, Pereira, Renata O., Brahma, Manoja K., Tuinei, Joseph, Contreras-Ferrat, Ariel, Wang, Li, Andrizzi, Chase A., Olsen, Curtis D., Bradley, Wayne E., Dell’Italia, Louis J., Dillmann, Wolfgang H., Litwin, Sheldon E., Abel, E. Dale |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506832/ https://www.ncbi.nlm.nih.gov/pubmed/32366681 http://dx.doi.org/10.2337/db19-1057 |
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