Decreased AMP‐activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury

We investigated the hypothesis that exposure of lungs at the saccular stage of development to hyperoxia leads to persistent growth arrest and dysfunction of 5’AMP‐activated protein kinase (AMPK), a key energy sensor in the cell. We exposed neonatal rat pups from postnatal day 1‐ day 10 (P1–P10) to ≥...

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Detalles Bibliográficos
Autores principales: Yadav, Abha, Rana, Ujala, Michalkiewicz, Teresa, Teng, Ru‐Jeng, Konduri, Girija G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507093/
https://www.ncbi.nlm.nih.gov/pubmed/32959498
http://dx.doi.org/10.14814/phy2.14587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507093/
https://www.ncbi.nlm.nih.gov/pubmed/32959498
http://dx.doi.org/10.14814/phy2.14587

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