Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

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Detalles Bibliográficos
Autores principales: Campisi, Marco, Sundararaman, Shriram K., Shelton, Sarah E., Knelson, Erik H., Mahadevan, Navin R., Yoshida, Ryohei, Tani, Tetsuo, Ivanova, Elena, Cañadas, Israel, Osaki, Tatsuya, Lee, Sharon Wei Ling, Thai, Tran, Han, Saemi, Piel, Brandon P., Gilhooley, Sean, Paweletz, Cloud P., Chiono, Valeria, Kamm, Roger D., Kitajima, Shunsuke, Barbie, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507350/
https://www.ncbi.nlm.nih.gov/pubmed/33013881
http://dx.doi.org/10.3389/fimmu.2020.02090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507350/
https://www.ncbi.nlm.nih.gov/pubmed/33013881
http://dx.doi.org/10.3389/fimmu.2020.02090

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