Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells

Phosphodiesterase 3 (PDE3), of which there are two isoforms, PDE3A and PDE3B, hydrolyzes cAMP and cGMP—cyclic nucleotides important in the regulation of pulmonary vascular tone. PDE3 has been implicated in pulmonary hypertension unresponsive to nitric oxide (NO); however, contributions of the two is...

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Detalles Bibliográficos
Autores principales: Dillard, Julie, Meng, Xiaomei, Nelin, Leif, Liu, Yusen, Chen, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507575/
https://www.ncbi.nlm.nih.gov/pubmed/32914566
http://dx.doi.org/10.14814/phy2.14559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507575/
https://www.ncbi.nlm.nih.gov/pubmed/32914566
http://dx.doi.org/10.14814/phy2.14559

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