Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures

INTRODUCTION: Selecting individuals at high risk of Alzheimer's disease (AD) dementia and using the most sensitive outcome measures are important aspects of trial design. METHODS: We divided participants from Alzheimer's Disease Neuroimaging Initiative at the 50th percentile of the predict...

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Detalles Bibliográficos
Autores principales: Banks, Sarah J., Qiu, Yuqi, Fan, Chun Chieh, Dale, Anders M., Zou, Jingjing, Askew, Brianna, Feldman, Howard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507583/
https://www.ncbi.nlm.nih.gov/pubmed/32999917
http://dx.doi.org/10.1002/trc2.12071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507583/
https://www.ncbi.nlm.nih.gov/pubmed/32999917
http://dx.doi.org/10.1002/trc2.12071

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