Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level

BACKGROUND: Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a remarkable therapeutic efficacy, despite its small demethylating effect. Here,...

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Detalles Bibliográficos
Autores principales: Takeshima, Hideyuki, Yoda, Yukie, Wakabayashi, Mika, Hattori, Naoko, Yamashita, Satoshi, Ushijima, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507826/
https://www.ncbi.nlm.nih.gov/pubmed/32958049
http://dx.doi.org/10.1186/s13148-020-00937-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507826/
https://www.ncbi.nlm.nih.gov/pubmed/32958049
http://dx.doi.org/10.1186/s13148-020-00937-y

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