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Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level
BACKGROUND: Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a remarkable therapeutic efficacy, despite its small demethylating effect. Here,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507826/ https://www.ncbi.nlm.nih.gov/pubmed/32958049 http://dx.doi.org/10.1186/s13148-020-00937-y |