Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study

BACKGROUND: Coronary slow-flow phenomenon (CSFP), characterized by delayed distal vessel opacification of contrast, in the absence of significant epicardial coronary stenosis, has effects on exercise capacity and clinical outcomes. The aim of this study was to explore the systolic and diastolic func...

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Autores principales: Seyyed-Mohammadzad, Mir Hossein, Rashtchizadeh, Sanam, Khademvatani, Kamal, Afsargharehbagh, Roghaiyeh, Nasiri, Aliakbar, Sepehrvand, Nariman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507914/
https://www.ncbi.nlm.nih.gov/pubmed/33014297
http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_119_18
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author Seyyed-Mohammadzad, Mir Hossein
Rashtchizadeh, Sanam
Khademvatani, Kamal
Afsargharehbagh, Roghaiyeh
Nasiri, Aliakbar
Sepehrvand, Nariman
author_facet Seyyed-Mohammadzad, Mir Hossein
Rashtchizadeh, Sanam
Khademvatani, Kamal
Afsargharehbagh, Roghaiyeh
Nasiri, Aliakbar
Sepehrvand, Nariman
author_sort Seyyed-Mohammadzad, Mir Hossein
collection PubMed
description BACKGROUND: Coronary slow-flow phenomenon (CSFP), characterized by delayed distal vessel opacification of contrast, in the absence of significant epicardial coronary stenosis, has effects on exercise capacity and clinical outcomes. The aim of this study was to explore the systolic and diastolic function of patients with CSFP and to compare it with a group of controls with normal coronary anatomy and flow. MATERIALS AND METHODS: In this case–control study, 45 consecutive CSFP patients and 45 age-, body mass index-, and presentation season-matched controls with normal coronary arteries and normal coronary flows were enrolled from Seyyedoshohada Heart Center from March 2015 to March 2016. A transthoracic echocardiography was done by a blinded echocardiographer using both conventional and tissue Doppler imaging techniques. RESULTS: Patients with CSFP were more likely to be male (P = 0.006) and smoker (P = 0.02) compared to controls. Other risk factors were not different between the two groups. There were no differences between groups in terms of the peak early (E) and late (A) diastolic velocities, deceleration time, early (E’) and late (A’) peak diastolic velocities at the mitral annulus, and the systolic mitral annular velocity (S’). Global longitudinal strain and peak systolic strain rates was lower in patients with CSFP compared to controls (−16.7% ±2.4% vs. −18.9% ±1.6%, P < 0.001 and 1.10 ± 0.1 vs. 1.24 ± 0.3, P = 0.008, respectively). CONCLUSION: Patients with CSFP showed signs of the left ventricular systolic dysfunction in tissue Doppler echocardiography, which underlines the importance of close follow-up in these patients. Patients with CSFP should be screened for ventricular function preferably by tissue Doppler echocardiography.
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spelling pubmed-75079142020-10-02 Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study Seyyed-Mohammadzad, Mir Hossein Rashtchizadeh, Sanam Khademvatani, Kamal Afsargharehbagh, Roghaiyeh Nasiri, Aliakbar Sepehrvand, Nariman Heart Views Original Article BACKGROUND: Coronary slow-flow phenomenon (CSFP), characterized by delayed distal vessel opacification of contrast, in the absence of significant epicardial coronary stenosis, has effects on exercise capacity and clinical outcomes. The aim of this study was to explore the systolic and diastolic function of patients with CSFP and to compare it with a group of controls with normal coronary anatomy and flow. MATERIALS AND METHODS: In this case–control study, 45 consecutive CSFP patients and 45 age-, body mass index-, and presentation season-matched controls with normal coronary arteries and normal coronary flows were enrolled from Seyyedoshohada Heart Center from March 2015 to March 2016. A transthoracic echocardiography was done by a blinded echocardiographer using both conventional and tissue Doppler imaging techniques. RESULTS: Patients with CSFP were more likely to be male (P = 0.006) and smoker (P = 0.02) compared to controls. Other risk factors were not different between the two groups. There were no differences between groups in terms of the peak early (E) and late (A) diastolic velocities, deceleration time, early (E’) and late (A’) peak diastolic velocities at the mitral annulus, and the systolic mitral annular velocity (S’). Global longitudinal strain and peak systolic strain rates was lower in patients with CSFP compared to controls (−16.7% ±2.4% vs. −18.9% ±1.6%, P < 0.001 and 1.10 ± 0.1 vs. 1.24 ± 0.3, P = 0.008, respectively). CONCLUSION: Patients with CSFP showed signs of the left ventricular systolic dysfunction in tissue Doppler echocardiography, which underlines the importance of close follow-up in these patients. Patients with CSFP should be screened for ventricular function preferably by tissue Doppler echocardiography. Wolters Kluwer - Medknow 2020 2020-06-29 /pmc/articles/PMC7507914/ /pubmed/33014297 http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_119_18 Text en Copyright: © 2020 Heart Views http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Seyyed-Mohammadzad, Mir Hossein
Rashtchizadeh, Sanam
Khademvatani, Kamal
Afsargharehbagh, Roghaiyeh
Nasiri, Aliakbar
Sepehrvand, Nariman
Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title_full Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title_fullStr Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title_full_unstemmed Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title_short Ventricular Dysfunction in Patients with Coronary Slow-Flow Phenomenon: A Single-center Case–control Study
title_sort ventricular dysfunction in patients with coronary slow-flow phenomenon: a single-center case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507914/
https://www.ncbi.nlm.nih.gov/pubmed/33014297
http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_119_18
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