Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity

Repeat expansion mutations in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG translation of this expansion produces dipeptide repeat proteins (DRPs). The arginine containing DRPs, polyGR and polyP...

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Detalles Bibliográficos
Autores principales: Premasiri, Alan S., Gill, Anna L., Vieira, Fernando G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508178/
https://www.ncbi.nlm.nih.gov/pubmed/33013410
http://dx.doi.org/10.3389/fphar.2020.569661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508178/
https://www.ncbi.nlm.nih.gov/pubmed/33013410
http://dx.doi.org/10.3389/fphar.2020.569661

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