Cargando…

Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity

Repeat expansion mutations in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG translation of this expansion produces dipeptide repeat proteins (DRPs). The arginine containing DRPs, polyGR and polyP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Premasiri, Alan S., Gill, Anna L., Vieira, Fernando G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508178/ https://www.ncbi.nlm.nih.gov/pubmed/33013410 http://dx.doi.org/10.3389/fphar.2020.569661

Ejemplares similares

Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD
por: Gill, Anna L., et al.
Publicado: (2021)

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
por: Hayes, Lindsey R, et al.
Publicado: (2020)

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins
por: Viera Ortiz, Ashley P, et al.
Publicado: (2022)

Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges
por: Miyagi, Tamami, et al.
Publicado: (2023)

Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides
por: Kanekura, Kohsuke, et al.
Publicado: (2018)

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
por: Nanaura, Hitoki, et al.
Publicado: (2021)

C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons
por: Kim, Eun Seon, et al.
Publicado: (2021)

Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells
por: Gill, Anna L., et al.
Publicado: (2019)

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome
por: Gupta, Rahul, et al.
Publicado: (2017)

C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
por: Sun, Yu, et al.
Publicado: (2020)

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity
por: Flores, Brittany N., et al.
Publicado: (2016)

C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons
por: Park, Jeong Hyang, et al.
Publicado: (2020)

Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
por: Sun, Yu, et al.
Publicado: (2022)

The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD
por: Freibaum, Brian D., et al.
Publicado: (2017)

Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags
por: Morón-Oset, Javier, et al.
Publicado: (2023)

Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans
por: Rudich, Paige, et al.
Publicado: (2017)

Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD
por: Schmitz, Alexander, et al.
Publicado: (2021)

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
por: Fumagalli, Laura, et al.
Publicado: (2021)

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
por: Moens, Thomas G., et al.
Publicado: (2019)

Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size
por: Bennion Callister, Janis, et al.
Publicado: (2016)

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
por: Boeynaems, Steven, et al.
Publicado: (2017)

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response
por: Shiota, Tomo, et al.
Publicado: (2022)

Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
por: Cykowski, Matthew D., et al.
Publicado: (2019)

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
por: Ohki, Yu, et al.
Publicado: (2017)

Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins
por: Zhou, Qihui, et al.
Publicado: (2017)

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity
por: Kramer, Nicholas J., et al.
Publicado: (2018)

Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity
por: Xu, Wangchao, et al.
Publicado: (2019)

Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression
por: McGoldrick, Philip, et al.
Publicado: (2018)

Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
por: Bennett, Craig L., et al.
Publicado: (2023)

SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72
por: Malnar, Mirjana, et al.
Publicado: (2021)

Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders
por: Boivin, Manon, et al.
Publicado: (2020)

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration
por: May, Stephanie, et al.
Publicado: (2014)

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA
por: Božič, Janja, et al.
Publicado: (2021)

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance
por: Jiménez-Villegas, José, et al.
Publicado: (2022)

Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model
por: Frottin, Frédéric, et al.
Publicado: (2021)

Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
por: Schludi, Martin H., et al.
Publicado: (2015)

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
por: Tabet, Ricardos, et al.
Publicado: (2018)

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients
por: Mordes, Daniel A., et al.
Publicado: (2018)

Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease
por: Sakae, Nobutaka, et al.
Publicado: (2018)

Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
por: Liu, Feilin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mbqbbed8bjbugeu5ne2esm8rqt