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Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion
Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrP(Sc), onto the cell-expressed conformer, PrP(C). Here we study the conversion of PrP(C) to PrP(Sc) using a reco...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508373/ https://www.ncbi.nlm.nih.gov/pubmed/32898162 http://dx.doi.org/10.1371/journal.ppat.1008875 |