Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion

Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrP(Sc), onto the cell-expressed conformer, PrP(C). Here we study the conversion of PrP(C) to PrP(Sc) using a reco...

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Detalles Bibliográficos
Autores principales: Burke, Cassandra M., Mark, Kenneth M. K., Walsh, Daniel J., Noble, Geoffrey P., Steele, Alexander D., Diack, Abigail B., Manson, Jean C., Watts, Joel C., Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508373/
https://www.ncbi.nlm.nih.gov/pubmed/32898162
http://dx.doi.org/10.1371/journal.ppat.1008875

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