Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice

The development of an effective vaccine against SARS-CoV-2 is urgently needed. We generated SARS-CoV-2 RBD-Fc fusion protein and evaluated its potency to elicit neutralizing antibody response in mice. RBD-Fc elicited a higher neutralizing antibodies titer than RBD as evaluated by a pseudovirus neutr...

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Detalles Bibliográficos
Autores principales: Liu, Xianglei, Drelich, Aleksandra, Li, Wei, Chen, Chuan, Sun, Zehua, Shi, Megan, Adams, Cynthia, Mellors, John W., Tseng, Chien-Te, Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508516/
https://www.ncbi.nlm.nih.gov/pubmed/33010978
http://dx.doi.org/10.1016/j.vaccine.2020.09.058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508516/
https://www.ncbi.nlm.nih.gov/pubmed/33010978
http://dx.doi.org/10.1016/j.vaccine.2020.09.058

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