Cargando…

Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice

The development of an effective vaccine against SARS-CoV-2 is urgently needed. We generated SARS-CoV-2 RBD-Fc fusion protein and evaluated its potency to elicit neutralizing antibody response in mice. RBD-Fc elicited a higher neutralizing antibodies titer than RBD as evaluated by a pseudovirus neutr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xianglei, Drelich, Aleksandra, Li, Wei, Chen, Chuan, Sun, Zehua, Shi, Megan, Adams, Cynthia, Mellors, John W., Tseng, Chien-Te, Dimitrov, Dimiter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Ltd. 2020
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508516/ https://www.ncbi.nlm.nih.gov/pubmed/33010978 http://dx.doi.org/10.1016/j.vaccine.2020.09.058

Ejemplares similares

Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
por: Sun, Zehua, et al.
Publicado: (2020)

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
por: Liu, Xianglei, et al.
Publicado: (2021)

Protocol for constructing large size human antibody heavy chain variable domain (V(H)) library and selection of SARS-CoV-2 neutralizing antibody domains
por: Chen, Chuan, et al.
Publicado: (2021)

Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine
por: Li, Chia-Jung, et al.
Publicado: (2023)

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
por: Li, Wei, et al.
Publicado: (2020)

Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn
por: Gong, Rui, et al.
Publicado: (2012)

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains
por: Chen, Chuan, et al.
Publicado: (2022)

Assessment of Novel Mesothelin-Specific Human Antibody Domain VH-Fc Fusion Proteins-Based PET Agents
por: Sun, Zehua, et al.
Publicado: (2023)

The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires
por: Prabakaran, Ponraj, et al.
Publicado: (2014)

Bepridil is potent against SARS-CoV-2 In Vitro
por: Vatansever, Erol C., et al.
Publicado: (2020)

High Potency of a Bivalent Human V(H) Domain in SARS-CoV-2 Animal Models
por: Li, Wei, et al.
Publicado: (2020)

Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22
por: Sun, Zehua, et al.
Publicado: (2022)

Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
por: Chen, Chuan, et al.
Publicado: (2022)

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
por: Mannar, Dhiraj, et al.
Publicado: (2022)

Identification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies
por: Yang, Zheng, et al.
Publicado: (2015)

Bepridil is potent against SARS-CoV-2 in vitro
por: Vatansever, Erol C., et al.
Publicado: (2021)

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
por: Zhu, Xing, et al.
Publicado: (2021)

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice
por: Li, Yaohui, et al.
Publicado: (2020)

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses
por: Yang, Yongping, et al.
Publicado: (2021)

Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate
por: Sun, Zehua, et al.
Publicado: (2023)

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays
por: Curreli, Francesca, et al.
Publicado: (2021)

Immunization With Fc-Based Recombinant Epstein–Barr Virus gp350 Elicits Potent Neutralizing Humoral Immune Response in a BALB/c Mice Model
por: Zhao, Bingchun, et al.
Publicado: (2018)

A potent human neutralizing antibody Fc-dependently reduces established HBV infections
por: Li, Dan, et al.
Publicado: (2017)

Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro
por: Curreli, Francesca, et al.
Publicado: (2020)

Enhancement of immunogenicity and neutralizing responses against SARS-CoV-2 spike protein using the Fc fusion fragment
por: Ehteshaminia, Yahya, et al.
Publicado: (2023)

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
por: McCoy, Laura E., et al.
Publicado: (2012)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
por: Bowen, John E., et al.
Publicado: (2022)

Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery
por: Liu, Cuiping, et al.
Publicado: (2023)

Adeno‐associated virus‐vectored influenza vaccine elicits neutralizing and Fcγ receptor‐activating antibodies
por: Demminger, Daniel E, et al.
Publicado: (2020)

ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern
por: Tsai, Tsung-I, et al.
Publicado: (2022)

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases
por: Chu, Xiaojie, et al.
Publicado: (2021)

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
por: Ying, Tianlei, et al.
Publicado: (2015)

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes
por: Li, Leike, et al.
Publicado: (2019)

Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents
por: Zhu, Jiyun, et al.
Publicado: (2022)

Interactions of IgG1 CH2 and CH3 Domains with FcRn
por: Ying, Tianlei, et al.
Publicado: (2014)

Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody
por: Khalil, Ahmed M., et al.
Publicado: (2023)

An insulin growth factor-I/II-neutralizing monoclonal antibody in combination with epidermal growth factor receptor inhibitors potently inhibits tumor cell growth
por: Ma, Guofang, et al.
Publicado: (2022)

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates
por: Ren, Wenlin, et al.
Publicado: (2020)

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells
por: Vazquez-Lombardi, Rodrigo, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eh50hmlji43if1cqkp1nvrbrbl