IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

Enterovirus 71 (EV71) poses serious threats to human health, particularly in Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem loop II structure of the EV71 internal ribosomal entry site as vital to viral translation and a potential target. After screening an...

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Detalles Bibliográficos
Autores principales: Davila-Calderon, Jesse, Patwardhan, Neeraj N., Chiu, Liang-Yuan, Sugarman, Andrew, Cai, Zhengguo, Penutmutchu, Srinivasa R., Li, Mei-Ling, Brewer, Gary, Hargrove, Amanda E., Tolbert, Blanton S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508794/
https://www.ncbi.nlm.nih.gov/pubmed/32963221
http://dx.doi.org/10.1038/s41467-020-18594-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508794/
https://www.ncbi.nlm.nih.gov/pubmed/32963221
http://dx.doi.org/10.1038/s41467-020-18594-3

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