DNA minor-groove binder Hoechst 33258 destabilizes base-pairing adjacent to its binding site

Understanding the dynamic interactions of ligands to DNA is important in DNA-based nanotechnologies. By structurally tracking the dissociation of Hoechst 33258-bound DNA (d(CGCAAATTTGCG)(2)) complex (H-DNA) with T-jump 2D-IR spectroscopy, the ligand is found to strongly disturb the stability of the...

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Detalles Bibliográficos
Autores principales: Zhang, Xin-Xing, Brantley, Shelby L., Corcelli, Steven A., Tokmakoff, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508854/
https://www.ncbi.nlm.nih.gov/pubmed/32963293
http://dx.doi.org/10.1038/s42003-020-01241-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508854/
https://www.ncbi.nlm.nih.gov/pubmed/32963293
http://dx.doi.org/10.1038/s42003-020-01241-4

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