Cargando…

DNA minor-groove binder Hoechst 33258 destabilizes base-pairing adjacent to its binding site

Understanding the dynamic interactions of ligands to DNA is important in DNA-based nanotechnologies. By structurally tracking the dissociation of Hoechst 33258-bound DNA (d(CGCAAATTTGCG)(2)) complex (H-DNA) with T-jump 2D-IR spectroscopy, the ligand is found to strongly disturb the stability of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xin-Xing, Brantley, Shelby L., Corcelli, Steven A., Tokmakoff, Andrei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508854/ https://www.ncbi.nlm.nih.gov/pubmed/32963293 http://dx.doi.org/10.1038/s42003-020-01241-4

Ejemplares similares

Mouse-human heterokaryon analysis with a 33258 Hoechst-Giemsa technique
Publicado: (1975)

UV-induced Spectral Shift and Protonation of DNA Fluorescent Dye Hoechst 33258
por: Żurek-Biesiada, Dominika, et al.
Publicado: (2014)

Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents
por: Zhang, Dongjian, et al.
Publicado: (2018)

K(Ca)3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells
por: Bukhari, Maurish, et al.
Publicado: (2020)

Development of Novel (191)Pt-Labeled Hoechst33258: (191)Pt Is More Suitable than (111)In for Targeting DNA
por: Obata, Honoka, et al.
Publicado: (2022)

Minor Groove Binder Distamycin Remodels Chromatin but Inhibits Transcription
por: Majumder, Parijat, et al.
Publicado: (2013)

Reduced nuclear binding of a DNA minor groove ligand (Hoechst 33342) and its impact on cytotoxicity in drug resistant murine cell lines.
por: Morgan, S. A., et al.
Publicado: (1990)

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition
por: Harika, Narinder K., et al.
Publicado: (2016)

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics
por: Scott, Fraser J., et al.
Publicado: (2016)

Synthesis and Evaluation of Novel DNA Minor Groove Binders as Antiamoebic Agents
por: Alniss, Hasan Y., et al.
Publicado: (2022)

THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves
por: Sabogal, Alex, et al.
Publicado: (2009)

Dissociation of minor groove binders from DNA: insights from metadynamics simulations
por: Vargiu, Attilio Vittorio, et al.
Publicado: (2008)

New Insight into the Molecular Mechanisms of the Biological Effects of DNA Minor Groove Binders
por: Zhang, Xinbo, et al.
Publicado: (2011)

Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
por: Kawashima, Etsuko, et al.
Publicado: (2010)

Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders
por: Kennedy, Alan R., et al.
Publicado: (2017)

Ratiometric imaging of minor groove binders in mammalian cells using Raman microscopy
por: Tentellino, Christian, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Modeling of Dimeric PPI Analogues as Novel DNA Minor Groove Binders
por: Yang, Yan-Hui, et al.
Publicado: (2008)

Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
por: Perieteanu, Marina C., et al.
Publicado: (2022)

Disruption of energetic and dynamic base pairing cooperativity in DNA duplexes by an abasic site
por: Ashwood, Brennan, et al.
Publicado: (2023)

A rapid minor groove binder PCR method for distinguishing the vaccine strain Brucella abortus 104M
por: Nan, Wenlong, et al.
Publicado: (2018)

A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves
por: Rodríguez, Jéssica, et al.
Publicado: (2016)

Specific minor groove solvation is a crucial determinant of DNA binding site recognition
por: Harris, Lydia-Ann, et al.
Publicado: (2014)

Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours.
por: Olive, P. L., et al.
Publicado: (1985)

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA–protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
por: Millan, Cinthia R., et al.
Publicado: (2017)

Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity
por: Costas-Lago, María Carmen, et al.
Publicado: (2022)

α-Bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity
por: Marchini, S, et al.
Publicado: (1999)

Brostallicin (PNU-166196) – a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells
por: Fedier, A, et al.
Publicado: (2003)

RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder
por: Oh, Juntaek, et al.
Publicado: (2022)

Monkeypox virus detection in rodents using real-time 3′-minor groove binder TaqMan® assays on the Roche LightCycler
por: Kulesh, David A, et al.
Publicado: (2004)

A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context
por: Paul, Ananya, et al.
Publicado: (2019)

Effect of DNA Groove Binder Distamycin A upon Chromatin Structure
por: Majumder, Parijat, et al.
Publicado: (2011)

Sustained Release of Minor-Groove-Binding Antibiotic Netropsin from Calcium-Coated Groove-Rich DNA Particles
por: Jeon, Hyunsu, et al.
Publicado: (2019)

Detection of Norovirus genogroup I and II by multiplex real-time RT- PCR using a 3'-minor groove binder-DNA probe
por: Hoehne, Marina, et al.
Publicado: (2006)

Detection of Fusobacterium spp in colorectal tissue samples using reverse transcription polymerase chain reaction with minor groove binder probes: an exploratory research
por: Silva, Cláudio J.N., et al.
Publicado: (2018)

Ein Fastbus-VSB Interface fuer hoechste Raten
por: Weymann, M
Publicado: (1993)

The Effect of Hoechst 33342 on Luciferase Gene Transcription and Translation
por: Zhang, Xinbo, et al.
Publicado: (2001)

Disruption of nucleosomes by DNA groove binders of clinical significance and implications for chromatin remodeling
por: Lorch, Yahli, et al.
Publicado: (2022)

What drives the binding of minor groove-directed ligands to DNA hairpins?
por: Lah, Jurij, et al.
Publicado: (2008)

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
por: Garabedian, Alyssa, et al.
Publicado: (2022)

A minor groove binder probe real-time PCR assay for discrimination between type 2-based vaccines and field strains of canine parvovirus
por: Decaro, Nicola, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_vl3hmn0276gh0rnbg27r1458d4