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Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae
Streptococcus pneumoniae choline kinase (sChoK) has previously been proposed as a drug target, yet the effectiveness of the first and only known inhibitor of sChoK, HC-3, is in the millimolar range. The aim of this study was thus to further validate sChoK as a potential therapeutic target by discove...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508948/ https://www.ncbi.nlm.nih.gov/pubmed/32963303 http://dx.doi.org/10.1038/s41598-020-72165-6 |