Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells

The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic potentials. To understand the role of microRNAs...

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Detalles Bibliográficos
Autores principales: Jung, Yi-deun, Park, Seul-Ki, Kang, Dayeon, Hwang, Supyong, Kang, Myoung-Hee, Hong, Seung-Woo, Moon, Jai-Hee, Shin, Jae-Sik, Jin, Dong-Hoon, You, Dalsan, Lee, Joo-Yong, Park, Yun-Yong, Hwang, Jung Jin, Kim, Choung Soo, Suh, Nayoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509080/
https://www.ncbi.nlm.nih.gov/pubmed/32961441
http://dx.doi.org/10.1016/j.redox.2020.101716

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