A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia

A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential has been limited by toxicity and water...

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Detalles Bibliográficos
Autores principales: Datan, Emmanuel, Minn, Il, Xu, Peng, He, Qing-Li, Ahn, Hye-Hyun, Yu, Biao, Pomper, Martin G., Liu, Jun O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509213/
https://www.ncbi.nlm.nih.gov/pubmed/33083765
http://dx.doi.org/10.1016/j.isci.2020.101536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509213/
https://www.ncbi.nlm.nih.gov/pubmed/33083765
http://dx.doi.org/10.1016/j.isci.2020.101536

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